Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction
| Autor: | Loukianos S. Rallidis, Dimitrios Th. Kremastinos, Ioannis Lekakis, Christoforos Komporozos, Argiro Gialeraki, Anthi Travlou, Panagiotis Vavoulis, Georgios P Pavlakis |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Homocysteine Myocardial Infarction Coronary Angiography Polymorphism Single Nucleotide Gastroenterology chemistry.chemical_compound Folic Acid Internal medicine Odds Ratio Humans Medicine Genetic Predisposition to Disease Myocardial infarction Methylenetetrahydrofolate Reductase (NADPH2) biology business.industry Vascular disease Case-control study Odds ratio medicine.disease Coronary Vessels Confidence interval Coronary arteries Endocrinology medicine.anatomical_structure chemistry Case-Control Studies Methylenetetrahydrofolate reductase biology.protein Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Atherosclerosis. 200:115-120 |
| ISSN: | 0021-9150 |
| Popis: | The pathogenetic mechanism of premature myocardial infarction (MI) remains unknown. We explored the association of homocysteine and its main genetic modulator methylenetetrahydrofolate reductase (MTHFR) 677C-T polymorphism with the development of MIor=35 years of age.We performed a case-control study of 147 patients with a first MIor=35 years and 103 age and sex-matched controls. We assessed plasma lipids, homocysteine, folate, vitamin B(12) levels and MTHFR 677C-T polymorphism.Patients with premature MI had higher homocysteine levels (13.9+/-8.6 vs. 11.8+/-4.9 mmol/l, p=0.02) and higher prevalence of TT homozygocity compared to controls (27.1% vs. 14.6%, p=0.02). Thirty-four patients (23.6%) had angiographically "normal" coronary arteries. Subgroup analysis according to angiographic findings ("normal" coronary arteries versus significant coronary heart disease) showed that only patients with MI and "normal" coronary arteries (MINCA) had higher homocysteine levels compared to controls (17.6+/-12.2 vs. 11.8+/-4.9 mmol/l, p0.001). The prevalence of TT genotype was higher only in patients with MINCA compared to controls (44.1% vs. 14.6%, p=0.001) (odds ratio 4.6, 95% confidence interval (CI), 1.9-11, p=0.001). This association remained after adjusting for conventional risk factors (odds ratio 3.4, 95% CI, 1.1-10.4, p=0.03). The adjusted odds ratio for MINCA of young individuals with MTHFR TT genotype and folate levels in the lowest quartile (or=5 ng/ml) was 6.1 (95% CI, 1.1-31, p=0.04).Homozygocity for the 677C-T mutation of MTHFR is independently associated with the development of premature MINCA. |
| Databáze: | OpenAIRE |
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