Regulation of retinal angiogenesis by phospholipase C-β3 signaling pathway
| Autor: | Seo Yeon Jin, Dong Hyung Lee, Seung-Hoon Baek, Hye Sun Lee, Sun Sik Bae, Young-Hwan Kim, Hwa Kyoung Shin, Sang Heon Song, Jung Min Ha, Sun Ja Kim, Chi Dae Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Angiogenesis Clinical Biochemistry Phospholipase C beta Neovascularization Physiologic Phospholipase Biology Biochemistry Umbilical vein Neovascularization 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Cell Movement Cell Line Tumor medicine Human Umbilical Vein Endothelial Cells Animals Humans Gene Silencing Molecular Biology Cell Proliferation Tube formation Phospholipase C Retinal Vessels Retinal Cell biology Endothelial stem cell 030104 developmental biology chemistry 030220 oncology & carcinogenesis Molecular Medicine Original Article medicine.symptom Signal Transduction |
| Zdroj: | Experimental & Molecular Medicine |
| ISSN: | 2092-6413 1226-3613 |
| Popis: | Angiogenesis has an essential role in many pathophysiologies. Here, we show that phospholipase C-β3 (PLC-β3) isoform regulates endothelial cell function and retinal angiogenesis. Silencing of PLC-β3 in human umbilical vein endothelial cells (HUVECs) significantly delayed proliferation, migration and capillary-like tube formation. In addition, mice lacking PLC-β3 showed impaired retinal angiogenesis with delayed endothelial proliferation, reduced endothelial cell activation, abnormal vessel formation and hemorrhage. Finally, tumor formation was significantly reduced in mice lacking PLC-β3 and showed irregular size and shape of blood vessels. These results suggest that regulation of endothelial function by PLC-β3 may contribute to angiogenesis. |
| Databáze: | OpenAIRE |
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