Low doses of methylmercury exposure during adulthood in rats display oxidative stress, neurodegeneration in the motor cortex and lead to impairment of motor skills
| Autor: | Lílian Lund Amado, Maria Elena Crespo-Lopez, Francisco Bruno Teixeira, Luanna Melo Pereira Fernandes, Lygia Sega Nogueira, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Luana Nazaré da Silva Santana, Cristiane Socorro Ferraz Maia, Rafael Monteiro Fernandes, Márcia Cristina Freitas da Silva, Leonardo Oliveira Bittencourt |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system 010501 environmental sciences medicine.disease_cause 01 natural sciences Biochemistry Inorganic Chemistry 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Motor skill 0105 earth and related environmental sciences Dose-Response Relationship Drug business.industry Neurodegeneration Motor Cortex Motor control Environmental exposure Methylmercury Compounds medicine.disease Rats Oxidative Stress Endocrinology medicine.anatomical_structure Motor Skills Nerve Degeneration Molecular Medicine business Motor learning 030217 neurology & neurosurgery Oxidative stress Motor cortex |
| Zdroj: | Journal of Trace Elements in Medicine and Biology. 51:19-27 |
| ISSN: | 0946-672X |
| DOI: | 10.1016/j.jtemb.2018.09.004 |
| Popis: | Despite the vast distribution among tissues, the central nervous system (CNS) represents the main target of methylmercury (MeHg) toxicity. However, few studies have evaluated the effects of MeHg exposure on the CNS at equivalent doses to human environmental exposure. In our study, we evaluated the motor cortex, an important area of motor control, in adult rats chronically exposed to MeHg in a concentration equivalent to those found in fish-eating populations exposed to mercury (Hg). The parameters evaluated were total Hg accumulation, oxidative stress, tissue damage, and behavioral assessment in functional actions that involved this cortical region. Our results show in exposed animals a significantly greater level of Hg in the motor cortex; increase of nitrite levels and lipid peroxidation, associated with decreased antioxidant capacity against peroxyl radicals; reduction of neuronal and astrocyte density; and poor coordination and motor learning impairment. Our data showed that chronic exposure at low doses to MeHg is capable of promoting damages to the motor cortex of adult animals, with changes in oxidative biochemistry misbalance, neurodegeneration, and motor function impairment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect