Potassium channel KCNH2 K897T polymorphism and cardiac repolarization during exercise test: The Finnish Cardiovascular Study
| Autor: | Tiit Kööbi, R. Lehtinen, Väinö Turjanmaa, J. Laiho, Terho Lehtimäki, Mika Kähönen, Tuomo Nieminen, Jenni Koskela, Jari Viik, Matti Niemi, Kari Niemelä, Ilkka Pörsti, Riikka Rontu |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male ERG1 Potassium Channel medicine.medical_specialty Adolescent Genotype Clinical Biochemistry Blood Pressure Single-nucleotide polymorphism Physical exercise Biology Polymorphism Single Nucleotide QT interval Cohort Studies Electrocardiography Sex Factors Gene Frequency Heart Rate Polymorphism (computer science) Internal medicine medicine Humans Repolarization Finland Aged Aged 80 and over Analysis of Variance Beta-adrenergic blocking agent Myocardium Heart General Medicine Middle Aged Ether-A-Go-Go Potassium Channels Potassium channel Endocrinology Exercise Test Cardiology Female |
| Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 68:31-38 |
| ISSN: | 1502-7686 0036-5513 |
| DOI: | 10.1080/00365510701496488 |
| Popis: | Cardiac repolarization is regulated, in part, by the KCNH2 gene, which encodes a rapidly activating component of the delayed rectifier potassium channel. The gene expresses a functional single nucleotide polymorphism, K897T, which changes the biophysical properties of the channel. The objective of this study was to evaluate whether this polymorphism influences two indices of repolarization--the QT interval and T-wave alternans (TWA)--during different phases of a physical exercise test.The cohort consisted of 1,975 patients undergoing an exercise test during which on-line electrocardiographic data were registered. Information on coronary risk factors and medication was recorded. The 2690AC nucleotide variation in the KCNH2 gene corresponding to the K897T amino acid change was analysed after polymerase chain reaction with allele-specific TaqMan probes.Among all subjects, the QTc intervals did not differ between the three genotype groups (por =0.31, RANOVA). Women with the CC genotype tended to have longer QT intervals during the exercise test, but the difference was statistically significant only at rest (p = 0.011, ANOVA). This difference was also detected when the analysis was adjusted for several factors influencing the QT interval. No statistically significant effects of the K897T polymorphism on TWA were observed among all subjects (p = 0.16, RANOVA), nor in men and women separately.The K897T polymorphism of the KCNH2 gene may not be a major genetic determinant for the TWA, but the influence of the CC genotype on QT interval deserves further research among women. |
| Databáze: | OpenAIRE |
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