The Influence of Renal Function Impairment on Kappa Free Light Chains in Cerebrospinal Fluid
| Autor: | Torsten Witte, Philipp Schwenkenbecher, Kurt-Wolfram Sühs, Matthias Grothe, Stefan Gingele, Ulrich Wurster, Franz Felix Konen, Marie Süße, Malte Johannes Hannich, Konstantin Fritz Jendretzky, Nora Möhn, Martin Stangel, Thomas Skripuletz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Renal function Reference range Review Article Immunoglobulin light chain cerebrospinal fluid chemistry.chemical_compound Cerebrospinal fluid Internal medicine eGFR medicine RC346-429 Creatinine biology business.industry renal function kappa free light chains (KFLC) reiber’s diagram Endocrinology chemistry biology.protein biomarker Biomarker (medicine) Neurology. Diseases of the nervous system Antibody business Kappa |
| Zdroj: | Journal of Central Nervous System Disease, Vol 13 (2021) Journal of Central Nervous System Disease |
| ISSN: | 1179-5735 |
| Popis: | Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin concentrations, interpretation of KFLC in CSF may be influenced by these parameters. Methods In this two-center study, the influence of renal function (according to the CKD-EPI creatinine equation) on KFLC and albumin concentrations was investigated in patients with “physiological” (n = 139), “non-inflammatory” (n = 146), and “inflammatory” (n = 172) CSF profiles in respect to the KFLC index and the evaluation in quotient diagrams in reference to the hyperbolic reference range (KFLC IF). Results All sample groups displayed declining KFLC indices and KFLC IF values with decreasing renal function ( P-values between Kappa(lim), suggesting possible false negative KFLC results. Conclusions The influence of renal function should be considered while interpreting KFLC results in patients with neuroinflammatory diseases. The interpretation of KFLC in quotient diagrams is less susceptible to renal function impairment than the KFLC index and should be preferentially used. |
| Databáze: | OpenAIRE |
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