The mathematical evaluation of flow-through cytophotometric data in processing cervical cytology
| Autor: | Reinhard Rossner, E. Sprenger, W. Sandritter, Ch. Otto, M. Schaden |
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| Rok vydání: | 1974 |
| Předmět: |
Percentile
Statistics as Topic nutritional and metabolic diseases Papanicolaou stain Uterine Cervical Neoplasms Cervical cytology General Medicine DNA Linear discriminant analysis Pathology and Forensic Medicine Cytogenetics Discriminant Statistics Cervix Mucus Methods Humans Mass Screening False Positive Reactions Female False Negative Reactions Mathematics |
| Zdroj: | Beitrage zur Pathologie. 153(3) |
| ISSN: | 0005-8165 |
| Popis: | Summary The flow-through cytophotometric determination of cell nuclear DNA content should be employed as a cervical cytological prescreening procedure. The goal of a mathematical evaluation of measured results is the fewest possible number of false negative findings consistent with an acceptably small number of false positive findings which must be redone. The statistical method for deciding whether an individual belongs to one of two possible groups is discriminant analysis. The difference between each of eight, selected percentiles and the diploid peak were employed as parameters for the frequency distribution. Comparison of the numerical results of discriminant analysis to simultaneous determinations after Papanicolaou resulted in an empirically obtained critical value for the classification of the discriminant values. The application of this process results in rates of 33% false positive findings and 5% false negative findings. |
| Databáze: | OpenAIRE |
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