Assessment of the efficacy of orally administered afoxolaner against Rhipicephalus sanguineus sensu lato
| Autor: | Sean Daly, Pascal Dumont, Bruce N. Kunkle, Diane Larsen, Marlene Drag |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
Veterinary medicine Rhipicephalus sanguineus Administration Oral Naphthalenes Tick Oral efficacy Single oral dose Random Allocation Dogs Afoxolaner parasitic diseases Dog Animals Dog Diseases Acaricides integumentary system General Veterinary biology Acaricide Isoxazoles General Medicine bacterial infections and mycoses biology.organism_classification veterinary(all) Tick Infestations Treatment Outcome Female Parasitology After treatment |
| Zdroj: | Veterinary Parasitology. 201:226-228 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2014.02.018 |
| Popis: | Two studies were conducted to confirm that a single oral dose of the novel insecticide/acaricide afoxolaner is efficacious against existing infestations of Rhipicephalus sanguineus sensu lato in dogs and can control re-infestation for up to 35 days. Each study utilized 16 purpose bred adult dogs using a controlled randomized block design. One or two days prior to treatment, all dogs were infested with 50 unfed adult ticks. On Day 0 one group was treated with an oral chewable formulation of afoxolaner at a dose as close as possible to the minimum dose of 2.5 mg/kg. Weekly re-infestations with 50 adult unfed ticks were repeated for five weeks. Forty-eight hours after treatment and after each re-infestation, the number of remaining live ticks on each dog was counted. Treatment with afoxolaner resulted in efficacies of 98.8–100% within 48 h on existing tick infestations, while the efficacy against new tick infestations was >95.7% over five weeks. |
| Databáze: | OpenAIRE |
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