Effect of Cascade Plasma Filtration on Spectrum of Subfractions of Low Density Lipoproteins in Blood Plasma of Patients with Ischemic Heart Disease
| Autor: | E. Utkina, I Iu Adamova, Marat V. Ezhov, Maya S. Safarova, R. N. Adzhiev, Pokrovskiĭ Sn, O I Afanas'eva, N V Artem'eva |
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| Předmět: |
Adult
Male medicine.medical_specialty Apolipoprotein B medicine.medical_treatment Drug Resistance Myocardial Ischemia Hyperlipidemias Plasma filtration chemistry.chemical_compound Internal medicine Hemofiltration Hyperlipidemia Blood plasma medicine Humans Hypolipidemic Agents Monitoring Physiologic biology Cholesterol business.industry Cholesterol LDL Middle Aged medicine.disease Lipoproteins LDL Endocrinology Treatment Outcome chemistry LDL apheresis Apolipoprotein B-100 biology.protein Cardiology lipids (amino acids peptides and proteins) Female Cardiology and Cardiovascular Medicine Ischemic heart business |
| Zdroj: | ResearcherID Europe PubMed Central Scopus-Elsevier |
| Popis: | We studied effect of cascade plasma filtration on subfractions of low density lipoproteins (LDL) in 16 patients with ischemic heart disease (IHD) and hyperlipidemias refractory to drug therapy. The procedure caused 37.6 ± 1.4%, 43.1 ± 2.5%, and 50.9 ± 1.4% lowering of total, low density lipoprotein cholesterol, and apolipoprotein B-100, respectively. The use of filters led to removal of larger less atherogenic LDL-1 and LDL-2 subfractions with relative accumulation of small dense LDL-3, LDL-4, and LDL-5 subfractions. Lowering of concentrations of all LDL subfractions was caused by specific LDL apheresis by immunosorbtion in 4 patients with IHD. Removal of small dense LDL was more effective than that of large less atherogenic LDL-1 and LDL-2 subfraction. Thus we found differences in spectrum of LDL removed by cascade plasma filtration and immunosorbtion. The use of filters was associated with less effective removal of most atherogenic small dense LDL than of large LDL particles what led to redistribution of concentrations of various LDL subfractions towards atherogenic profile of lipoproteins. These results could constitute a basis for revision of methods of conduct of cascade plasma filtration procedures in patients with IHD. |
| Databáze: | OpenAIRE |
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