Neonatal Thrombocytopenia in HLA-DR, -DQ, -DP-Typed Mother due to Rare Anti-HPA-1b (PLA2) (Zwb) Fetomaternal Immunization
| Autor: | C. Dabanian, D. Reviron, M. Diallo, Y. Delord, Pascale Mercier, F. Bourgue, C. Chicheportiche, Jacques Chiaroni |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Platelet Transfusion Biology Neonatal Thrombocytopenia Antigen Isoantibodies Pregnancy medicine Humans Antigens Human Platelet Blood Transfusion Platelet Typing Maternal-Fetal Exchange Purpura HLA-D Antigens Platelet Count Infant Newborn Hematology General Medicine medicine.disease Thrombocytopenia Immunization Immunoglobulin G Neonatal alloimmune thrombocytopenia Monoclonal Immunology biology.protein Female Antibody Immunity Maternally-Acquired |
| Zdroj: | Vox Sanguinis. 67:46-51 |
| ISSN: | 1423-0410 0042-9007 |
| Popis: | A new case of rare neonatal alloimmune thrombocytopenia, due to an IgG anti-HPA-1b in a mother HPA-1 (a+, b-), was diagnosed using monoclonal antibody-specific immobilization of platelet antigens. Clinically, it was similar to the 2 previously reported observations and confirmed that, in this particular case of anti-HPA-1b, the treatment with random platelet pools may be as effective as selected single-donor platelet units when maternal platelets are unusable. The HLA-DR, -DQ, -DP genotypes of the family were obtained by PCR-SSO. The mother's typing, compared to the HLA-DR of the 6 similar cases reported in Europe, suggests that a combined effect of two rare HLA haplotypes might enhance this immunization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text