Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
| Autor: | Eva Thiemann, Carmen Navarrete, Cristina Cruz-Teno, Eduardo Muñoz, Kurt Appel, Andreas Biller |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Allergy Immulina® mast cells Inflammation Plant Science Pharmacology Inhibitory postsynaptic potential Immunoglobulin E Polysaccharide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine ImmunLoges Ecology Evolution Behavior and Systematics chemistry.chemical_classification Innate immune system Ecology biology Activator (genetics) Botany allergy inflammation immunLoges® medicine.disease 030104 developmental biology chemistry QK1-989 030220 oncology & carcinogenesis biology.protein Mast cells medicine.symptom Histamine |
| Zdroj: | Plants 7, 13 (2018) Helvia. Repositorio Institucional de la Universidad de Córdoba instname Plants; Volume 7; Issue 1; Pages: 13 Plants, Vol 7, Iss 1, p 13 (2018) |
| Popis: | Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also exert inhibitory effects in the induced allergic inflammatory response and on histamine release from RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen complex-induced production of TNF- , IL-4, leukotrienes and histamine. The compound 48/80 stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release of histamine from mast cells. |
| Databáze: | OpenAIRE |
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