High levels of pretreatment and acquired HIV drug resistance in Nicaragua: results from the first nationally representative survey, 2016
| Autor: | Edgar Sajquim, Daniela Tapia-Trejo, Claudia García-Morales, Luz Romero, Carlos Vargas, Matilde Román, René Gutiérrez, Giovanni Ravasi, Marissa Pérez-García, Verónica S Quiroz-Morales, Gustavo Reyes-Terán, Ricardo Mendizabal-Burastero, Aleyda Solórzano, Sandra I Juárez, Sanny Northbrook, Santiago Ávila-Ríos, Amalia Girón-Callejas |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Anti-HIV Agents antiretroviral therapy Short Report Human immunodeficiency virus (HIV) Nicaragua HIV Infections Drug resistance World Health Organization medicine.disease_cause National cohort Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Short Reports Surveys and Questionnaires Internal medicine Drug Resistance Viral Prevalence Humans Medicine 030212 general & internal medicine treatment failure High rate drug resistance 030505 public health business.industry Public Health Environmental and Occupational Health HIV Survey research Viral Load Antiretroviral therapy Cross-Sectional Studies Infectious Diseases surveillance HIV-1 Female 0305 other medical science business Viral load HIV drug resistance |
| Zdroj: | Journal of the International AIDS Society |
| ISSN: | 1758-2652 |
| DOI: | 10.1002/jia2.25429 |
| Popis: | Introduction A nationally representative HIV drug resistance (HIVDR) survey in Nicaragua was conducted to estimate the prevalence of pretreatment HIVDR (PDR) among antiretroviral therapy (ART) initiators and acquired HIVDR among people living with HIV (PLHIV) who had received ART for 12 ± 3 months (ADR12) and ≥48 months (ADR48). Methods A nationwide cross‐sectional survey with a two‐stage cluster sampling was conducted from March to November 2016. Nineteen of 45 total ART clinics representing >90% of the national cohort of adults on ART were included. ART initiators were defined as PLHIV initiating or reinitiating first‐line ART. HIVDR was assessed for protease, reverse transcriptase and integrase Sanger sequences using the Stanford HIVdb algorithm. Viral load (VL) suppression was defined as |
| Databáze: | OpenAIRE |
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