The Murine CD99-Related Molecule CD99-Like 2 (CD99L2) Is an Adhesion Molecule Involved in the Inflammatory Response

Autor:	William A. Muller, Eric M. Dufour, Tina W. Chew, Alan R. Schenkel, Emily Sorg
Rok vydání:	2007
Předmět:	Endothelium Molecular Sequence Data Clinical Biochemistry Inflammation 12E7 Antigen Biology Transfection Antibodies Mice Antigen Antigens CD Sequence Homology Nucleic Acid Chlorocebus aethiops E-selectin Cell Adhesion Leukocytes medicine Animals Humans Cells Cultured Sequence Homology Amino Acid Cell Membrane Endothelial Cells Cell Biology General Medicine Molecular biology Rats Inbred F344 Rats Cell biology Chemotaxis Leukocyte Thymocyte Red blood cell medicine.anatomical_structure Antigens Surface COS Cells biology.protein Female Rabbits medicine.symptom Antibody Cell Adhesion Molecules
Zdroj:	Cell Communication & Adhesion. 14:227-237
ISSN:	1543-5180 1541-9061
Popis:	CD99, a glycoprotein found on the surfaces of leukocytes and concentrated at the borders of endothelial cells, plays a major role in the migration of leukocytes across endothelial cells into sites of inflammation, and has other roles in thymocyte development. The human and mouse genomes encode only two proteins related to CD99. One of these, XGA, is a red blood cell surface antigen. The function of the other, CD99-like 2 (CD99L2), is not known. We cloned mouse CD99L2 and used CD99L2 isolated from transfected cells to raise specific antibodies. Similar to human CD99, CD99L2 was expressed at the borders between transfected cells as well as on mouse leukocytes and vascular endothelial cells in situ. Transfection of L cell fibroblasts with CD99L2 imparted to them the ability to adhere to each other in a divalent cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked influx of neutrophils and monocytes into a site of inflammation in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051802d18380b9289222bd0e1b9fd7df https://doi.org/10.1080/15419060701755966 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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