Gait disorder as a predictor of spatial learning and memory impairment in aged mice
| Autor: | Zhaoxiang Meng, Qing M. Wang, Zhenglu Yin, Xun Luo, Duonan Yu, Xin Wang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Coefficient of variation Cadence Gait disorders lcsh:Medicine Morris water navigation task 050105 experimental psychology General Biochemistry Genetics and Molecular Biology Correlation 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Stride length medicine Memory impairment 0501 psychology and cognitive sciences Quantitative gait assessment Receiver operating characteristic business.industry General Neuroscience lcsh:R 05 social sciences Cognition Morris water maze test General Medicine Base of support Aged mice Gait Average speed Cognitive impairment Gait analysis General Agricultural and Biological Sciences business human activities 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PeerJ, Vol 5, p e2854 (2017) PeerJ |
| ISSN: | 2167-8359 |
| DOI: | 10.7717/peerj.2854 |
| Popis: | Objective To investigate whether gait dysfunction is a predictor of severe spatial learning and memory impairment in aged mice. Methods A total of 100 12-month-old male mice that had no obvious abnormal motor ability and whose Morris water maze performances were not significantly different from those of two-month-old male mice were selected for the study. The selected aged mice were then divided into abnormal or normal gait groups according to the results from the quantitative gait assessment. Gaits of aged mice were defined as abnormal when the values of quantitative gait parameters were two standard deviations (SD) lower or higher than those of 2-month-old male mice. Gait parameters included stride length, variability of stride length, base of support, cadence, and average speed. After nine months, mice exhibiting severe spatial learning and memory impairment were separated from mice with mild or no cognitive dysfunction. The rate of severe spatial learning and memory impairment in the abnormal and normal gait groups was tested by a chi-square test and the correlation between gait dysfunction and decline in cognitive function was tested using a diagnostic test. Results The 12-month-old aged mice were divided into a normal gait group (n = 75) and an abnormal gait group (n = 25). Nine months later, three mice in the normal gait group and two mice in the abnormal gait group had died. The remaining mice were subjected to the Morris water maze again, and 17 out of 23 mice in the abnormal gait group had developed severe spatial learning and memory impairment, including six with stride length deficits, 15 with coefficient of variation (CV) in stride length, two with base of support (BOS) deficits, five with cadence dysfunction, and six with average speed deficits. In contrast, only 15 out of 72 mice in the normal gait group developed severe spatial learning and memory impairment. The rate of severe spatial learning and memory impairment was significantly higher in the abnormal gait group as compared to that in the normal gait group (x = 21.986, P P Conclusion Gait disorders are a predictor of severe spatial learning and memory impairment in aged mice, and stride length, variability of stride length, base of support, cadence, and average speed are all sensitive parameters for assessing gait. |
| Databáze: | OpenAIRE |
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