Transdermal iontophoretic delivery of hydrocortisone from cyclodextrin solutions
| Autor: | Shu-Lun Chang, Ajay K. Banga |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Hydrocortisone
medicine.drug_class Chemistry Pharmaceutical Anti-Inflammatory Agents Pharmaceutical Science Beta-Cyclodextrins Pharmacology Administration Cutaneous Dosage form Permeability Skin Physiological Phenomena medicine Cadaver Humans Transdermal Active ingredient Cyclodextrins Aqueous solution Chromatography Iontophoresis Chemistry beta-Cyclodextrins Permeation Propylene Glycol Solvents Corticosteroid Pharmaceutical Vehicles |
| Zdroj: | The Journal of pharmacy and pharmacology. 50(6) |
| ISSN: | 0022-3573 |
| Popis: | Enhanced skin penetration of hydrocortisone can be desirable for treatment of several diseases. Transdermal iontophoretic delivery of hydrocortisone solubilized in an aqueous solution of hydroxypropyl-β-cyclodextrin (HP-β-CyD) was investigated and compared with chemical enhancement of co-solvent formulations. The passive permeation of hydrocortisone through human cadaver skin was higher when delivered from propylene glycol than when delivered after solubilization in an aqueous solution of HP-β-CyD. However, the iontophoretic delivery of the 1% hydrocortisone-9% HP-β-CyD solution was higher than the amount delivered passively by the 1% hydrocortisone-propylene glycol formulation, even if oleic acid was used as a chemical enhancer. Iontophoretic delivery of 1% hydrocortisone with 3% or 15% HP-β-CyD was lower than that of the 9% HP-β-CyD solution. These data suggest that free hydrocortisone rather than complexes is predominantly delivered iontophoretically through the skin and the HP-β-CyD complex serves as a carrier to replenish depletion of hydrocortisone. HP-β-CyD prevents hydrocortisone from forming a skin reservoir. Iontophoresis provides better enhancement of transdermal delivery of hydrocortisone than the chemical approach when just sufficient HP-β-CyD is added to solubilize the hydrocortisone. |
| Databáze: | OpenAIRE |
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