A Revised Hemodynamic Theory of Age-Related Macular Degeneration
| Autor: | Bradley D. Gelfand, Jayakrishna Ambati |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Pathology genetic structures Central blindness Hemodynamics Audiology Article Pathogenesis Macular Degeneration 03 medical and health sciences 0302 clinical medicine Age related medicine Animals Humans Molecular Biology Retina Choroid business.industry Mechanism (biology) Macular degeneration medicine.disease eye diseases 030104 developmental biology medicine.anatomical_structure Disease Progression 030221 ophthalmology & optometry Molecular Medicine sense organs business |
| Zdroj: | Trends in Molecular Medicine. 22:656-670 |
| ISSN: | 1471-4914 |
| DOI: | 10.1016/j.molmed.2016.06.009 |
| Popis: | Age-related macular degeneration (AMD) afflicts one out of every 40 individuals worldwide, causing irreversible central blindness in millions. The transformation of various tissue layers within the macula in the retina has led to competing conceptual models of the molecular pathways, cell types, and tissues responsible for the onset and progression of AMD. A model that has persisted for over 6 decades is the hemodynamic, or vascular theory of AMD progression, which states that vascular dysfunction of the choroid underlies AMD pathogenesis. Here, we re-evaluate this hypothesis in light of recent advances on molecular, anatomic, and hemodynamic changes underlying choroidal dysfunction in AMD. We propose an updated, detailed model of hemodynamic dysfunction as a mechanism of AMD development and progression. |
| Databáze: | OpenAIRE |
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