Long-chain N-acylethanolamines inhibit lipid peroxidation in rat liver mitochondria under acute hypoxic hypoxia
| Autor: | Tetyana M. Goridko, N.M. Gulaya, Victor Margitich, Kuz'menko Ai, Nonna M. Govseeva, Alexander D. Zhukov, Sergij D. Melnichuk |
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| Rok vydání: | 1999 |
| Předmět: |
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Free Radicals Hypoxic hypoxia Iron Mitochondria Liver Palmitic Acids Mitochondrion Inhibitory postsynaptic potential Biochemistry Antioxidants law.invention Lipid peroxidation chemistry.chemical_compound law N-Acylethanolamine medicine Animals Rats Wistar Hypoxia Molecular Biology Chemiluminescence Chemistry Organic Chemistry Cell Biology Hypoxia (medical) Amides In vitro Rats Kinetics Ethanolamines Luminescent Measurements Lipid Peroxidation medicine.symptom Endocannabinoids |
| Zdroj: | Chemistry and physics of lipids. 97(1) |
| ISSN: | 0009-3084 |
| Popis: | Two long-chain N-acylethanolamines (NAEs), N-palmitoyl- (NPE) and N-stearoylethanolamine (NSE), are shown to inhibit an in vitro non-enzymatic Fe2+-induced free radical oxidation of lipids in the liver mitochondria of rats with hypoxic hypoxia. NSE appeared to be more effective than NPE in suppressing some kinetic parameters of the Fe2+-induced chemiluminescence. The inhibitory action of NAEs on non-enzymatic lipid peroxidation supports the idea that they possess membrane protective properties. |
| Databáze: | OpenAIRE |
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