Baseline Splenic Volume as a Prognostic Biomarker of FOLFIRI Efficacy and a Surrogate Marker of MDSC Accumulation in Metastatic Colorectal Carcinoma

Autor: Julie Blanc, Marc Porneuf, Corinne Sarda, François-Xavier Caroli-Bosc, Julie Niogret, Karine Le Malicot, Emeric Limagne, M. Baconnier, Pierre-Luc Etienne, Franck Audemar, S. Nguyen, C. Lombard-Bohas, Jean-Louis Legoux, Thomas Aparicio, Miguel Carreiro, Marion Thibaudin, François Ghiringhelli, Y. Rinaldi, Aurélie Bertaut, Christophe Locher
Přispěvatelé: Département d'oncologie médicale [Centre Georges-François Leclerc], Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Université Bourgogne Franche-Comté [COMUE] (UBFC), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), École Nationale Supérieure de Formation de l'Enseignement Agricole de Toulouse-Auzeville (ENSFEA), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hémodynamique, Interaction Fibrose et Invasivité tumorales Hépatiques (HIFIH), Université d'Angers (UA), Le CHCB, Centre Hospitalier de la Côte Basque, CHU Pau, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Grand Hôpital de l'Est Francilien (GHEF), Centre hospitalier de Montauban, Centre Hospitalier Régional d'Orléans (CHRO), Centre Armoricain de Radiothérapie, d'Imagerie médicale et d'Oncologie [Plérin, Saint-Brieuc] (CARIO), Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], Hôpital Yves LE FOLL [Saint-Brieuc], Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cancers
Volume 12
Issue 6
Cancers, MDPI, 2020, 12 (6), pp.1429. ⟨10.3390/cancers12061429⟩
Cancers, Vol 12, Iss 1429, p 1429 (2020)
ISSN: 2072-6694
DOI: 10.3390/cancers12061429
Popis: Background: Predictive biomarkers of response to chemotherapy plus antiangiogenic for metastatic colorectal cancer (mCRC) are lacking. The objective of this study was to test the prognostic role of splenomegaly on baseline CT scan. Methods: This study is a sub-study of PRODIGE-9 study, which included 488 mCRC patients treated by 5-fluorouracil, leucovorin and irinotecan (FOLFIRI) and bevacizumab in first line. The association between splenic volume, and PFS and OS was evaluated by univariate and multivariable Cox analyses. The relation between circulating monocytic Myeloid derived suppressor cells (mMDSC) and splenomegaly was also determined. Results: Baseline splenic volume >
180 mL was associated with poor PFS (median PFS = 9.2 versus 11.1 months
log-rank p = 0.0125), but was not statistically associated with OS (median OS = 22.6 versus 28.5 months
log-rank p = 0.1643). The increase in splenic volume at 3 months had no impact on PFS (HR 0.928
log-rank p = 0.56) or on OS (HR 0.843
log-rank p = 0.21). Baseline splenic volume was positively correlated with the level of baseline circulating mMDSC (r = 0.48, p-value = 0.031). Conclusion: Baseline splenomegaly is a prognostic biomarker in patients with mCRC treated with FOLFIRI and bevacizumab, and a surrogate marker of MDSC accumulation.
Databáze: OpenAIRE
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