Does clopidogrel change morbidity and mortality in ICU sepsis patients?
| Autor: | Donald G. Klepser, Keith M. Olsen, DA Roberts, AL Himmelberg, Timothy R. McGuire, Paul P. Dobesh |
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| Rok vydání: | 2014 |
| Předmět: |
Cardiovascular event
Mechanical ventilation medicine.medical_specialty business.industry medicine.medical_treatment Critical Care and Intensive Care Medicine medicine.disease Clopidogrel Sepsis Poster Presentation Emergency medicine medicine In patient cardiovascular diseases Intensive care medicine Adverse effect business Lower mortality Ticagrelor circulatory and respiratory physiology medicine.drug |
| Zdroj: | Critical Care |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/cc13428 |
| Popis: | The purpose of this study was to evaluate whether patients with sepsis exposed to clopidogrel have lower mortality and fewer days on mechanical ventilation compared with patients not exposed to clopidogrel. A recent post-hoc analysis of the PLATO trial suggests that the antiplatelet agent ticagrelor provided a significant reduction in sepsis-related mortality and pulmonary adverse events compared with clopidogrel. It is unknown whether clopidogrel also provides benefit in patients with sepsis compared with no therapy. Knowing this information may help focus future research on determining the mechanism of ticagrelor's benefit. |
| Databáze: | OpenAIRE |
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