High Rate of Serotype V Streptococcus agalactiae Carriage in Pregnant Women in Botswana
| Autor: | Evan Suzman, Anna B. Chamby, Brady A’Hearn-Thomas, Seeletso Nchingane, Adam J. Ratner, Margaret Gegick, Andrew P. Steenhoff, Tonya Arscott-Mills, Tara M. Randis, Tiny Mazhani, Ponatshego Gaolebale, Margaret Mokomane, Thabo Lepere, Francis Msume Banda, Ameneh Khatami, Moses Vurayai |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Serotype medicine.medical_specialty 030231 tropical medicine Mothers Serogroup medicine.disease_cause Group B Streptococcus agalactiae Young Adult 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors Streptococcal Infections Virology Epidemiology medicine Humans Pregnancy Complications Infectious Risk factor reproductive and urinary physiology Botswana Neonatal sepsis Obstetrics Transmission (medicine) business.industry Rectum Articles bacterial infections and mycoses medicine.disease Cross-Sectional Studies Infectious Diseases Carriage Carrier State Vagina Female Parasitology business |
| Zdroj: | Am J Trop Med Hyg |
| ISSN: | 1476-1645 0002-9637 |
| Popis: | Maternal rectovaginal colonization is the major risk factor for early-onset neonatal sepsis due to Group B Streptococcus (GBS), a major cause of early life morbidity and mortality. Transmission generally occurs perinatally from colonized mothers to infants. Vaccines targeting a subset of GBS serotypes are under development, but GBS epidemiology remains poorly understood in many African nations. We performed a cross-sectional study of GBS colonization among pregnant women at two sites in Botswana, a country with minimal prior GBS carriage data. We found a rectovaginal colonization rate of 19%, comparable with studies in other regions; however, we also noted a striking predominance of serotype V (> 45% of strains). Although further studies are required to delineate the burden of invasive GBS disease in Botswana and the generalizability of type V epidemiology, these data provide a useful baseline for understanding the potential local impact of GBS prevention strategies, including vaccines. |
| Databáze: | OpenAIRE |
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