In vivo endogenous spore formation by Coxiella burnetii in Q fever endocarditis
| Autor: | A J Galbraith, J P Gannon, T F McCaul, A J Dare |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Uranyl acetate Endogeny Q fever Biology Pathology and Forensic Medicine Microbiology chemistry.chemical_compound In vivo Sporogenesis medicine Humans Endocarditis Spores Bacterial Endocarditis Bacterial General Medicine Coxiella burnetii biology.organism_classification medicine.disease Heart Valves Virology Microscopy Electron Q fever endocarditis chemistry Q Fever Research Article |
| Zdroj: | Journal of Clinical Pathology. 47:978-981 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.47.11.978 |
| Popis: | AIMS--To determine whether Coxiella burnetii, the aetiological agent of Q fever, undergoes endogenous spore-like formation, the crucial stage of the developmental cycle, in the infected cardiac valves of patients with chronic Q fever endocarditis. METHODS--Surgically removed valves from three cases of Q fever endocarditis were processed for electron microscopy. Sections were stained with potassium permanganate and uranyl acetate before being extensively examined by transmission electron microscopy. RESULTS--In all three cases endogenous spore-like formation was seen in the infected cardiac valves. CONCLUSIONS--As the factors that govern sporogenesis in C burnetii are still largely unknown, it is uncertain how important are the implications of the discovery of endogenous spore-like formation in Q fever endocarditis. However, this finding may add new dimensions to current thinking about the treatment of chronic Q fever. |
| Databáze: | OpenAIRE |
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