Apolipoprotein A4-1/2 polymorphism and response of serum lipids to dietary cholesterol in humans
| Autor: | Harald Funke, Martijn B. Katan, S. Meyboom, Peter L. Zock, R.M. Weggemans |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Apolipoprotein B Saturated fat Blood lipids QD415-436 Biochemistry APOA4 chemistry.chemical_compound Endocrinology High-density lipoprotein Polymorphism (computer science) Internal medicine Genotype medicine VLAG Human Nutrition & Health Genetic polymorphism biology Cholesterol Humane Voeding & Gezondheid Cell Biology Diet ApoA-IV chemistry biology.protein lipids (amino acids peptides and proteins) Lipid response |
| Zdroj: | Journal of Lipid Research 41 (2000) Journal of Lipid Research, 41, 1623-1628 Journal of Lipid Research, Vol 41, Iss 10, Pp 1623-1628 (2000) Scopus-Elsevier |
| ISSN: | 0022-2275 |
| Popis: | The response of serum lipids to dietary changes is to some extent an innate characteristic. One candidate genetic factor that may affect the response of serum lipids to a change in cholesterol intake is variation in the apolipoprotein A4 gene, known as the APOA4-1/2 or apoA-IVGln360His polymorphism. However, previous studies showed inconsistent results. We therefore fed 10 men and 23 women with the APOA4-1/1 genotype and 4 men and 13 women with the APOA4-1/2 or -2/2 genotype (carriers of the APOA4-2 allele) two diets high in saturated fat, one containing cholesterol at 12.4 mg/MJ, 136.4 mg/day, and one containing cholesterol at 86.2 mg/MJ, 948.2 mg/day. Each diet was supplied for 29 days in crossover design. The mean response of serum low density lipoprotein cholesterol was 0.44 mmol/l (17 mg/dl) in both subjects with the APOA4-1/1 genotype and in subjects with the APOA4-2 allele [95% confidence interval of difference in response, −0.20 to 0.19 mmol/l (−8 to 7 mg/dl)]. The mean response of high density lipoprotein cholesterol was also similar, 0.10 mmol/l (4 mg/dl), in the two APOA-4 genotype groups [95% confidence interval of difference in response, −0.07 to 0.08 mmol/l (−3 to 3 mg/dl)]. Thus, the APOA4-1/2 polymorphism did not affect the response of serum lipids to a change in the intake of cholesterol in this group of healthy Dutch subjects who consumed a background diet high in saturated fat. Knowledge of the APOA4-1/2 polymorphism is probably not a generally applicable tool for the identification of subjects who respond to a change in cholesterol intake.—Weggemans, R. M., P. L. Zock, S. Meyboom, H. Funke, and M. B. Katan. Apolipoprotein A4-1/2 polymorphism and response of serum lipids to dietary cholesterol in humans. J. Lipid Res. 2000. 41: 1623–1628. |
| Databáze: | OpenAIRE |
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