Increased skin inflammation and blood vessel density in human and experimental diabetes

Autor: Eugenia Carvalho, Francesco Tecilazich, Michael E. Auster, Sarada Kuchibhotla, Leena Pradhan Nabzdyk, Aristidis Veves, Iraklis Kontoes, Antonios Kafanas, Jacqueline Paolino, Ana Tellechea, Ermelindo C. Leal
Přispěvatelé: Tellechea, Ana, Kafanas, Antonio, Leal, Ermelindo C., Tecilazich, Francesco, Kuchibhotla, Sarada, Auster, Michael E., Kontoes, Irakli, Paolino, Jacqueline, Carvalho, Eugenia, Nabzdyk, Leena Pradhan, Veves, Aristidis
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Pathology
Biopsy
diabetes
skin blood vessels
skin changes
skin inflammation
wound healing
Animals
Blood Vessels
Dermatitis
Diabetes Mellitus
Experimental
Diabetic Foot
Disease Progression
Female
Follow-Up Studies
Humans
Mice
Mice
Inbred BALB C
Middle Aged
Prospective Studies
Rabbits
Rats
Rats
Sprague-Dawley
Regional Blood Flow
Skin
Surgery
Rabbit
Systemic inflammation
skin change
Inbred BALB C
medicine.diagnostic_test
integumentary system
General Medicine
Diabetic foot ulcer
medicine.anatomical_structure
medicine.symptom
Blood vessel
Human
medicine.medical_specialty
Blood Vessel
Inflammation
Dermatiti
Article
Follow-Up Studie
Experimental
Diabetes mellitus
medicine
Diabetes Mellitus
business.industry
Animal
medicine.disease
Diabetic foot
Prospective Studie
diabete
Immunology
skin blood vessel
Rat
Sprague-Dawley
Wound healing
business
Popis: Systemic inflammation is associated with impaired wound healing in diabetes mellitus (DM) patients. Using immunohistochemistry techniques, the authors investigated changes in skin inflammation and skin blood vessels in human and experimental diabetes. Comparing to the non-DM human subjects, the total number of inflammatory cells per biopsy and the number of inflammatory cells around blood vessels, a strong indication of inflammation, were higher in DM subjects irrespective of their risk for developing diabetic foot ulcer. Inflammatory cell infiltration was robustly increased in all DM animal models compared with their non-DM controls. The number and density of blood vessels and CD31 positive proliferating endothelial cells around preexisting skin vessels was also higher in the DM patients. However, there were no differences in the skin blood flow between the non-DM and DM subjects. The number of skin blood vessels was also increased in the DM animals; however, these differences were less obvious than the ones observed for inflammatory cells. We conclude that skin inflammation and skin blood vessel density is increased in diabetic human subjects and in rodent and rabbit models of diabetes.
Databáze: OpenAIRE
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