Modulated transdermal delivery of nonsteroidal anti-inflammatory drug by macroporous poly(vinyl alcohol)-graphene oxide nanocomposite films
| Autor: | Meng-Jiy Wang, Shiu-Huey Chou, Alfin Kurniawan, Saitong Muneekaew, Chung-Wei Hung |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Vinyl alcohol
Materials science Polymer nanocomposite Pharmaceutical Science 02 engineering and technology Administration Cutaneous 030226 pharmacology & pharmacy Nanocomposites Diffusion layer 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Transdermal chemistry.chemical_classification Nanocomposite integumentary system Anti-Inflammatory Agents Non-Steroidal Oxides Polymer 021001 nanoscience & nanotechnology Controlled release Cellulose acetate Drug Liberation chemistry Chemical engineering Ketoprofen Polyvinyl Alcohol Graphite 0210 nano-technology |
| Zdroj: | International Journal of Pharmaceutics. 566:708-716 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2019.06.029 |
| Popis: | In this study, a facile, economically feasible, and scalable approach to fabricate macroporous poly(vinyl alcohol)-GO (PVA-GO) nanocomposite films with varying filler loadings was demonstrated. The nanocomposite films were prepared using a solvent casting process and employed as a diffusion layer for modulating the transdermal delivery of an anti-inflammatory drug (i.e., ketoprofen). The diffusion membrane was assembled in a three-layer structure with PVA/PVA-GO films between ketoprofen-loaded cellulose and cellulose acetate to mimic skin barrier. Through the incorporation of GO sheets into PVA matrix, the mass diffusion and drug release rate of ketoprofen could be modulated to attain a controlled-release system within period in comparison to that of neat PVA film, which showed more rapid release. It was observed that the dispersion level of GO sheets in the polymer matrix played a crucial role to slow the diffusion rate and drug release, where 3 wt% filler loading gave the slowest rate of release. The results from the present study shed light on the mechanism of and may provide guidelines for modulating drug release rates of NSAID in film-based delivery vehicles for transdermal delivery applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect