Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining
| Autor: | Masaru P. Rao, Patrick T. McCarthy, Kevin J. Otto |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Materials science Fabrication Biomedical Engineering chemistry.chemical_element Prosthesis Nanotechnology 02 engineering and technology Article Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Reliability (semiconductor) Thalamus Animals Microtechnology Molecular Biology Mechanical Phenomena Auditory Cortex Titanium Microelectromechanical systems Microstimulation Brain Equipment Design Prostheses and Implants Materials Engineering 021001 nanoscience & nanotechnology Nanoscience and Nanotechnology Rats Electrophysiological Phenomena Electrophysiology MEMS Brain-machine Surface micromachining Microelectrode chemistry Catastrophic failure Recording CEREBRAL-CORTEX SOMATOSENSORY SYSTEM PROSTHETIC DEVICES ELECTRODE ARRAYS UNIT RECORDINGS NERVOUS-SYSTEM RESPONSES DEXAMETHASONE IMPLANT PROBES 0210 nano-technology Microelectrodes 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | Biomedical microdevices, vol 13, iss 3 Birck and NCN Publications Biomedical Microdevices |
| ISSN: | 1572-8781 1387-2176 |
| Popis: | Neural prosthetic interfaces based upon penetrating microelectrode devices have broadened our understanding of the brain and have shown promise for restoring neurological functions lost to disease, stroke, or injury. However, the eventual viability of such devices for use in the treatment of neurological dysfunction may be ultimately constrained by the intrinsic brittleness of silicon, the material most commonly used for manufacture of penetrating microelectrodes. This brittleness creates predisposition for catastrophic fracture, which may adversely affect the reliability and safety of such devices, due to potential for fragmentation within the brain. Herein, we report the development of titanium-based penetrating microelectrodes that seek to address this potential future limitation. Titanium provides advantage relative to silicon due to its superior fracture toughness, which affords potential for creation of robust devices that are resistant to catastrophic failure. Realization of these devices is enabled by recently developed techniques which provide opportunity for fabrication of high-aspect-ratio micromechanical structures in bulk titanium substrates. Details are presented regarding the design, fabrication, mechanical testing, in vitro functional characterization, and preliminary in vivo testing of devices intended for acute recording in rat auditory cortex and thalamus, both independently and simultaneously. |
| Databáze: | OpenAIRE |
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