Magnetic targeting as a strategy to enhance therapeutic effects of mesenchymal stromal cells
| Autor: | Fernanda F. Cruz, Luisa H. A. Silva, Patricia R. M. Rocco, Marcelo M. Morales, Daniel J. Weiss |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Mesenchymal stromal cells Medicine (miscellaneous) Context (language use) Review 02 engineering and technology Mesenchymal Stem Cell Transplantation Regenerative Medicine Biochemistry Genetics and Molecular Biology (miscellaneous) Regenerative medicine Cell therapy Immunomodulation Magnetic targeting 03 medical and health sciences In vivo Humans Medicine Magnetite Nanoparticles business.industry Superparamagnetic nanoparticles Mesenchymal stem cell Magnetic devices Mesenchymal Stem Cells Cell Biology 021001 nanoscience & nanotechnology Cell delivery Surgery Magnetic Fields 030104 developmental biology Target site Cancer research Molecular Medicine Biocompatibility Stem cell 0210 nano-technology business human activities |
| Zdroj: | Stem Cell Research & Therapy |
| ISSN: | 1757-6512 |
| Popis: | Mesenchymal stromal cells (MSCs) have been extensively investigated in the field of regenerative medicine. It is known that the success of MSC-based therapies depends primarily on effective cell delivery to the target site where they will secrete vesicles and soluble factors with immunomodulatory and potentially reparative properties. However, some lesions are located in sites that are difficult to access, such as the heart, spinal cord, and joints. Additionally, low MSC retention at target sites makes cell therapy short-lasting and, therefore, less effective. In this context, the magnetic targeting technique has emerged as a new strategy to aid delivery, increase retention, and enhance the effects of MSCs. This approach uses magnetic nanoparticles to magnetize MSCs and static magnetic fields to guide them in vivo, thus promoting more focused, effective, and lasting retention of MSCs at the target site. In the present review, we discuss the magnetic targeting technique, its principles, and the materials most commonly used; we also discuss its potential for MSC enhancement, and safety concerns that should be addressed before it can be applied in clinical practice. |
| Databáze: | OpenAIRE |
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