Diastereo- and enantioselective rhodium(iii)-catalyzed reductive cyclization of cyclohexadienone-containing 1,6-dienes

Autor:	Wen-Bo Ye, Ping Tian, Guo-Qiang Lin, Pei-Ying Peng, Dingding Gao, Ya-Jie Wang, Yun-Xuan Tan, Xi-Liang Liu
Rok vydání:	2021
Předmět:	Stereochemistry Metals and Alloys Enantioselective synthesis chemistry.chemical_element General Chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials Rhodium Kinetic resolution Stereocenter chemistry Materials Chemistry Ceramics and Composites
Zdroj:	Chemical Communications. 57:9724-9727
ISSN:	1364-548X 1359-7345
DOI:	10.1039/d1cc03645a
Popis:	A diastereo- and enantioselective rhodium(III)-catalyzed reductive cyclization of cyclohexadienone-tethered terminal alkenes and (E)-1,2-disubstituted alkenes (1,6-dienes) is reported, providing cis-bicyclic products bearing three contiguous stereocenters with good yields and high diastereo- and enantioselectivities. The kinetic resolution of the racemic precursor is also achieved with good efficiency. Moreover, a subgram-scale experiment, several transformations of the cyclization product, and one-pot preparation of bridged polycyclic frameworks are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ff6fffc859a9875d3da18e17758170 https://doi.org/10.1039/d1cc03645a Zobrazit plný text záznamu