Isolation of ekatetrone, a new metabolite of producing variants of Streptomyces aureofaciens
| Autor: | V. Prikrylova, Margita Blumauerová, Zdenko Vanek, Miloslav Podojil |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Chemical Phenomena
medicine.drug_class Metabolite Streptomyces aureofaciens Anthraquinones Carboxamide Microbial Sensitivity Tests In Vitro Techniques Biology chemistry.chemical_compound Drug Discovery medicine Animals Carcinoma Ehrlich Tumor Pharmacology Antibiotics Antineoplastic Ekatetrone Valine biology.organism_classification Isolation (microbiology) In vitro Quinone Chemistry chemistry Biochemistry Fermentation Derivative (chemistry) |
| Zdroj: | The Journal of Antibiotics. 31:850-854 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.31.850 |
| Popis: | From a mixture of substances formed by producing strains of Streptomyces aureofaciens under conditions of submerged fermentation a new metabolite, ekatetrone, was isolated. Its isolation and basic physical and chemical data are described. Ekatetrone is a quinone derivative with a carboxamide group. In tests in vitro with cells of Ehrlich's ascites tumour evidence was provided that ekatetrone inhibits proteo- and nucleosynthesis. |
| Databáze: | OpenAIRE |
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