Alpha-Santalol, a Component of Sandalwood Oil Inhibits Migration of Breast Cancer Cells by Targeting the β-catenin Pathway
| Autor: | Terra Landis, Abigail Nemeth, Harsha P. Gorijavolu, Chandradhar Dwivedi, Adam L. VanWert, Ajay Bommareddy, Kacey Knapp, James Steigerwalt |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Sandalwood oil Cancer Research Apoptosis Breast Neoplasms 03 medical and health sciences Breast cancer Cell Movement Cell Line Tumor medicine Humans Plant Oils Wnt Signaling Pathway beta Catenin Polycyclic Sesquiterpenes Wound Healing Migration Assay Chemistry Wnt signaling pathway General Medicine medicine.disease In vitro 030104 developmental biology Oncology Catenin Cancer research MCF-7 Cells Female Wound healing Sesquiterpenes medicine.drug Signal Transduction |
| Zdroj: | Anticancer research. 38(8) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim Alpha-santalol, a terpenoid found in sandalwood oil has been shown to inhibit breast cancer cell growth in vitro by inducing apoptosis, but the mechanisms underlying the growth inhibitory effects of alpha-santalol are not fully understood. In this study, we demonstrate that α-santalol treatment targets Wnt/β-catenin pathway to inhibit migration of cultured breast cancer cells. Materials and methods Migration assays, immunoblotting and immunofluorescence were used to examine the mechanism of action of a-santalol in breast cancer cells. Results Exposure of MDA-MB 231 and MCF-7 cells to α-santalol resulted in a significant reduction in their migratory potential and wound healing ability. In addition, α-santalol affected the localization of β-catenin from cytosol to nucleus in MDA-MB 231 cells. Conclusion Alpha-santalol inhibited migration of breast cancer cells may be mediated, in part, by targeting Wnt//β-catenin pathway. β-catenin represents an important target of α-santalol's response for future pre-clinical studies. |
| Databáze: | OpenAIRE |
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