The chinchilla animal model for hearing science and noise-induced hearing loss
| Autor: | Edward Lobarinas, Michael G. Heinz, Amanda C. Maulden, Monica Trevino |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Chinchilla medicine.medical_specialty Acoustics and Ultrasonics Hearing loss Audiology 03 medical and health sciences 0302 clinical medicine Animal model Arts and Humanities (miscellaneous) Hearing Species Specificity biology.animal medicine otorhinolaryngologic diseases Auditory system Animals Humans biology Behavior Animal Extramural medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Hearing Loss Noise-Induced Special Issue on Noise-Induced Hearing Loss: Translating Risk from Animal Models to Real-World Environments medicine.symptom Psychology 030217 neurology & neurosurgery Noise-induced hearing loss |
| Zdroj: | The Journal of the Acoustical Society of America |
| ISSN: | 1520-8524 0001-4966 |
| Popis: | The chinchilla animal model for noise-induced hearing loss has an extensive history spanning more than 50 years. Many behavioral, anatomical, and physiological characteristics of the chinchilla make it a valuable animal model for hearing science. These include similarities with human hearing frequency and intensity sensitivity, the ability to be trained behaviorally with acoustic stimuli relevant to human hearing, a docile nature that allows many physiological measures to be made in an awake state, physiological robustness that allows for data to be collected from all levels of the auditory system, and the ability to model various types of conductive and sensorineural hearing losses that mimic pathologies observed in humans. Given these attributes, chinchillas have been used repeatedly to study anatomical, physiological, and behavioral effects of continuous and impulse noise exposures that produce either temporary or permanent threshold shifts. Based on the mechanistic insights from noise-exposure studies, chinchillas have also been used in pre-clinical drug studies for the prevention and rescue of noise-induced hearing loss. This review paper highlights the role of the chinchilla model in hearing science, its important contributions, and its advantages and limitations. |
| Databáze: | OpenAIRE |
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