Inhibition of fatty acid-supported mitochondrial respiration by cyclosporine
| Autor: | Jacob Rajfer, Carlos A.E. Lemmi, Raymond L. Miller |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Kidney Cortex Cellular respiration Endocrinology Diabetes and Metabolism Cyclosporins Biology Mitochondrion In Vitro Techniques Biochemistry Nephrotoxicity Oxygen Consumption medicine Animals Beta oxidation chemistry.chemical_classification Kidney Fatty Acids Palmitoylcarnitine Fatty acid Lipid metabolism Rats Inbred Strains Metabolism Mitochondria Rats medicine.anatomical_structure chemistry |
| Zdroj: | Biochemical medicine and metabolic biology. 44(3) |
| ISSN: | 0885-4505 |
| Popis: | We have shown that, in addition to inhibition of the succinate-supported energy pathway (5), CS inhibition of mitochondrial Complex II activity also limits fatty acid oxidation. These results are consistent with the participation of altered lipid metabolism in CS nephrotoxicity. |
| Databáze: | OpenAIRE |
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