Serum FSH Levels in Coasting Programmes on the hCG Day and Their Clinical Outcomes in IVF ± ICSI Cycles

Autor: Amanda J. Tozer, Talha Al-Shawaf, Jerome Bouaziz, Ariel Zosmer, S. Vitthala
Rok vydání: 2012
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2012 (2012)
International Journal of Endocrinology
ISSN: 1687-8345
1687-8337
Popis: Introduction. Coasting is the most commonly used strategy in prevention of severe OHSS. Serum FSH levels measurements during coasting may aid in optimizing the duration of coasting.Objective(s). To study live birth rates (LBRs), clinical pregnancy rates (CPRs), and optimal duration of coasting based on serum FSH levels on the hCG day.Materials and Methods.It is a retrospective study performed between 2005 and 2008 at Barts and The London Centre for Reproductive Medicine, NHS Trust, London, UK, on 349-coasted women undergoing controlled ovarian stimulation (COS) for IVF ± ICSI. The serum FSH level measurements on the hCG day during coasting programme were analysed to predict the LBR and CPR.Result(s). LBR and CPR were significantly higher when the FSH levels on the hCG day were >2.5 IU/L (LBR: 32.5%,P= 0.045 and CPR: 36.9%,P= 0.027) compared to FSH Conclusion(s). Coasting may be continued as long as either serum FSH level is > 2.5 IU/L on the hCG day without compromising the LBR and CPR or to maximum of 4 days.
Databáze: OpenAIRE