Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases
| Autor: | Ella M. van den Berg-Loonen, L. E. Nijenhuis, C. P. Engelfriet, S G Meuwissen, B J Dekker-Saeys |
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| Rok vydání: | 1977 |
| Předmět: |
musculoskeletal diseases
Ankylosing spondylitis Kell Blood-Group System Incidence (epidemiology) Histocompatibility Testing Immunology Human leukocyte antigen Disease Biology medicine.disease Inflammatory bowel disease Ulcerative colitis Histocompatibility Antigen Crohn Disease HLA Antigens Histocompatibility Antigens Genetics medicine Humans Colitis Ulcerative Spondylitis Ankylosing |
| Zdroj: | Journal of immunogenetics. 4(3) |
| ISSN: | 0305-1811 |
| Popis: | SUMMARY Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81.4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset. In addition to B27, another HLA antigen may be associated with AS; the antigen Bw16 was found to be significantly increased in B27 negative AS patients. HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bowel disease (IBD). In fifty-eight ulcerative colitis (UC) patients a raised incidence of A11 was noticed. In fifty-one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty-nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly different from the B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD an increased frequency of Bw16 was also shown. |
| Databáze: | OpenAIRE |
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