Does Extending the Waiting Time of Low-Rectal Cancer Surgery after Neoadjuvant Chemoradiation Increase the Perioperative Complications?
| Autor: | Ananya Pongpaibul, Suthinee Ithimakin, Thawatchai Akaraviputh, Janjira Petsuksiri, Vitoon Chinswangwatanakul, Atthaphorn Trakarnsanga, Kittinut Timudom, Natthawut Phothong |
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| Rok vydání: | 2016 |
| Předmět: |
Waiting time
medicine.medical_specialty Article Subject Hepatology Colorectal cancer business.industry Gastroenterology Locally advanced Perioperative 030230 surgery medicine.disease Tumor response Group B Circumferential margin Surgery 03 medical and health sciences 0302 clinical medicine Low rectal cancer 030220 oncology & carcinogenesis medicine lcsh:Diseases of the digestive system. Gastroenterology lcsh:RC799-869 business Research Article |
| Zdroj: | Gastroenterology Research and Practice Gastroenterology Research and Practice, Vol 2016 (2016) |
| ISSN: | 1687-6121 |
| Popis: | Background.Traditionally, rectal cancer surgery is recommended 6 to 8 weeks after completing neoadjuvant chemoradiation. Extending the waiting time may increase the tumor response rate. However, the perioperative complication rate may increase. The purpose of this study was to determine the association between extending the waiting time of surgery after neoadjuvant chemoradiation and perioperative outcomes.Methods. Sixty patients with locally advanced rectal cancer who underwent neoadjuvant chemoradiation followed by radical resection at Siriraj hospital between June 2012 and January 2015 were retrospectively analyzed. Demographic data and perioperative outcomes were compared between the two groups.Results. The two groups were comparable in term of demographic parameters. The mean time interval from neoadjuvant chemoradiation to surgery was 6.4 weeks in Group A and 11.7 weeks in Group B. The perioperative outcomes were not significantly different between Groups A and B. Pathologic examination showed a significantly higher rate of circumferential margin positivity in Group A than in Group B (30% versus 9.3%, resp.;P=0.04).Conclusions. Extending the waiting to >8 weeks from neoadjuvant chemoradiation to surgery did not increase perioperative complications, whereas the rate of circumferential margin positivity decreased. |
| Databáze: | OpenAIRE |
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