Raised Fibrinogen Levels and Outcome in Outpatients With Peripheral Artery Disease
| Autor: | Lorenzo Ramón Álvarez, Eduardo Aguilar, Pedro Enrique Jiménez, Joan Carles Sahuquillo, Juan Francisco Sánchez Muñoz-Torrero, Ana María García-Díaz, Paulina Perez, Manuel Monreal, Carlos Esteban, Pere Altes, Frena Investigators |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Arterial disease Myocardial Infarction Hemorrhage Disease 030204 cardiovascular system & hematology Fibrinogen Amputation Surgical Brain Ischemia 03 medical and health sciences Fibrinogen levels Peripheral Arterial Disease 0302 clinical medicine Risk Factors Internal medicine medicine Ambulatory Care Humans 030212 general & internal medicine Registries Aged business.industry Middle Aged Intermittent claudication Peripheral Stroke Spain Cardiology Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Angiology. 69(6) |
| ISSN: | 1940-1574 |
| Popis: | The influence of raised fibrinogen levels on outcome in stable outpatients with peripheral arterial disease (PAD) has not been consistently investigated. We used data from the Factores de Riesgo y ENfermedad Arterial (FRENA) registry to compare ischemic events, major bleeding, and mortality in stable outpatients with PAD, according to their baseline plasma fibrinogen levels. Of 1363 outpatients with PAD recruited in FRENA, 558 (41%) had fibrinogen levels >450 mg/100 mL. Over 18 months, 43 patients presented with acute myocardial infarction, 37 had an ischemic stroke, 51 underwent limb amputation, 19 had major bleeding, and 90 died. Compared to patients with normal levels, those with raised fibrinogen levels had an over 2-fold higher rate of ischemic stroke (rate ratio [RR]: 2.30; 95% confidence interval [CI]: 1.19-4.59), limb amputation (RR: 2.58; 95% CI: 1.46-4.67), or death (RR: 2.27; 95% CI: 1.49-3.51) and an over 3-fold higher rate of major bleeding (RR: 3.90; 95% CI: 1.45-12.1). On multivariate analysis, patients with raised fibrinogen levels had an increased risk of developing subsequent ischemic events (hazard ratio [HR]: 1.61; 95% CI: 1.11-2.32) and major bleeding (HR: 3.42; 95% CI: 1.22-9.61). Stable outpatients with PAD and raised plasma fibrinogen levels had increased rates of subsequent ischemic events and major bleeding. |
| Databáze: | OpenAIRE |
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