The Protective Effect of Anthocyanins Extracted from Aronia Melanocarpa Berry in Renal Ischemia-Reperfusion Injury in Mice

Autor:	Jun Li, Zhijun Li, Xu Hui, Fengmei Zhu, Lu Hongzhi, Liu Yongsheng, Jinrong Zhang, Li Li, Yang Zhengsheng
Rok vydání:	2021
Předmět:	Risk 0301 basic medicine Article Subject Immunology Renal function Apoptosis Pharmacology Kidney Antioxidants Anthocyanins Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Photinia Pathology RB1-214 Animals Medicine Inflammation Creatinine Renal ischemia business.industry Body Weight Acute kidney injury food and beverages Kidney metabolism Galactosides Cell Biology medicine.disease Caspase 9 Mice Inbred C57BL Oxidative Stress 030104 developmental biology medicine.anatomical_structure chemistry Fruit Reperfusion Injury 030220 oncology & carcinogenesis Reperfusion Kidney Failure Chronic Arabinonucleosides Lipid Peroxidation business Reperfusion injury Research Article Kidney disease
Zdroj:	Mediators of Inflammation Mediators of Inflammation, Vol 2021 (2021)
ISSN:	1466-1861 0962-9351
DOI:	10.1155/2021/7372893
Popis:	Background. Our previous research showed the antioxidant activity of anthocyanins extracted from Aronia melanocarpa of black chokeberry in vitro. Ischemia acute kidney injury is a significant risk in developing progressive and deterioration of renal function leading to clinic chronic kidney disease. There were many attempts to protect the kidney against this progression of renal damage. Current study was designed to examine the effect of pretreatment with three anthocyanins named cyanidin-3-arabinoside, cyanidin-3-glucodise, and cyaniding-3-galactoside against acute ischemia-reperfusion injury in mouse kidney. Methods. Acute renal injury model was initiated by 30 min clamping bilateral renal pedicle and followed by 24-hour reperfusion in C57Bl/6J mice. Four groups of mice were orally pretreated in 50 mg/g/12 h for two weeks with cyanidin-3-arabinoside, cyanidin-3-glucodise, and cyaniding-3-galactoside and anthocyanins (three-cyanidin mixture), respectively, sham-control group and the renal injury-untreated groups only with saline. Results. The model resulted in renal dysfunction with high serum creatinine, blood urea nitrogen, and changes in proinflammatory cytokines (TNF-ɑ, IL-1β, IL-6, and MCP-1), renal oxidative stress (SOD, GSH, and CAT), lipid peroxidation (TBARS and MDA), and apoptosis (caspase-9). Pretreatment of two weeks resulted in different extent amelioration of renal dysfunction and tubular damage and suppression of proinflammatory cytokines, oxidative stress, lipid peroxidation, and apoptosis, thus suggesting that cyanidins are potentially effective in acute renal ischemia by the decrease of inflammation, oxidative stress, and lipid peroxidation, as well as apoptosis. Conclusion. the current study provided the first attempt to investigate the role of anthocyanins purified from Aronia melanocarpa berry in amelioration of acute renal failure via antioxidant and cytoprotective effects.
Databáze:	OpenAIRE
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