The renal transport of hippurate and protein‐bound solutes
| Autor: | James Slater, Henriette de Loor, Björn Meijers, Joshua Novack, Jerome Lowenstein, Alex Etinger, Robert S. Holzman, Avinash Adiga, Rohit Kumar, Lawrence Chinitz |
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| Rok vydání: | 2020 |
| Předmět: |
Male
renal hemodynamics medicine.medical_specialty Physiology Vena Cava Inferior 030204 cardiovascular system & hematology Kidney Inferior vena cava lcsh:Physiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Renal transport Physiology (medical) Internal medicine protein-bound solutes medicine Humans Avidity Aged Original Research Renal Physiology Creatinine Renal tubule lcsh:QP1-981 Hippurates Blood Proteins hippurate clearance Effective renal plasma flow Middle Aged effective renal plasma flow Renal Elimination Endocrinology medicine.anatomical_structure chemistry medicine.vein Renal physiology protein‐bound solutes Female Cellular Physiology 030217 neurology & neurosurgery Protein Binding |
| Zdroj: | Physiological Reports Physiological Reports, Vol 8, Iss 4, Pp n/a-n/a (2020) |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.14349 |
| Popis: | Measurement of the concentration of hippurate in the inferior vena cava and renal blood samples performed in 13 subjects with normal or near‐normal serum creatinine concentrations confirmed the prediction that endogenous hippurate was cleared on a single pass through the kidney with the same avidity as that reported for infused para‐amino hippurate. This suggests that a timed urine collection without infusion would provide a measure of effective renal plasma flow. Comparison of the arteriovenous concentration differences for a panel of protein‐bound solutes identified solutes that were secreted by the renal tubule and solutes that were subjected to tubular reabsorption. The renal extraction of hippurate suggests that it can serve for the estimation of effective renal plasma flow without the need for infusion. The free (unbound) fraction of protein‐bound solutes are filtered at the glomerulus. Bound solutes are transported across the renal vascular bed, by organic anion transporters. |
| Databáze: | OpenAIRE |
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