Resveratrol enhances exercise training responses in rats selectively bred for high running performance
| Autor: | Zsolt Radak, Zsolt Csende, Erika Koltai, Lauren G. Koch, Dimitris Kouretas, Barbara Wessner, Kelvin J.A. Davies, Linda Sarga, Steven L. Britton, Nikolett Hart |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases AMP-Activated Protein Kinases Resveratrol Toxicology Antioxidants Article Running Mitochondrial Proteins Protein Carbonylation chemistry.chemical_compound Insulin resistance Sirtuin 1 AMP-activated protein kinase Endurance training Physical Conditioning Animal Internal medicine Stilbenes medicine Animals Treadmill skin and connective tissue diseases biology food and beverages General Medicine medicine.disease Mitochondria Rats DNA-Binding Proteins Oxidative Stress Endocrinology Mitochondrial biogenesis Biochemistry chemistry biology.protein Mitochondrial fission Insulin Resistance Reactive Oxygen Species Biomarkers hormones hormone substitutes and hormone antagonists Transcription Factors Food Science |
| Zdroj: | Food and Chemical Toxicology. 61:53-59 |
| ISSN: | 0278-6915 |
| DOI: | 10.1016/j.fct.2013.01.051 |
| Popis: | High capacity runner (HCR) rats have been developed by divergent artificial selection for treadmill endurance running capacity to explore an aerobic biology-disease connection. The beneficial effects of resveratrol supplementation have been demonstrated in endurance running and the antioxidant capacity of resveratrol is also demonstrated. In this study we examine whether 12 weeks of treadmill exercise training and/or resveratrol can enhance performance in HCR. Indeed, resveratrol increased aerobic performance and strength of upper limbs of these rats. Moreover, we have found that resveratrol activated the AMP-activated protein kinase, SIRT1, and mitochondrial transcription factor A (p |
| Databáze: | OpenAIRE |
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