Extracellular Electrical Stimulation-based in Vitro Neuroscience: A Minireview of Methods and a Paradigm Shift Proposal
| Autor: | Jari Hyttinen, Annika Ahtiainen, Jarno M. A. Tanskanen |
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| Přispěvatelé: | Tampere University, BioMediTech, Research group: Computational Biophysics and Imaging Group |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
03 medical and health sciences 030104 developmental biology 0302 clinical medicine 213 Electronic automation and communications engineering electronics Biological neural network Extracellular Neurochemistry Stimulation Biology Neuroscience 030217 neurology & neurosurgery In vitro |
| Zdroj: | 2019 26th IEEE International Conference on Electronics, Circuits and Systems (ICECS) ICECS |
| Popis: | Biological neuronal cells communicate using neurochemistry and electrical signals. Electrical stimulation (ES) is utilized to study neuronal cells and networks. Currently, ES is applied and responses observed in an open-loop fashion, which does not resemble natural network I/O. We hypothesize that real-time closed-loop full-duplex (simultaneous two-way) paradigms could provide deeper insight in natural neuronal networks, helping to understand our brains and to control neuronal network states to cure diseases. We present a minireview of ES-based extracellular in vitro neuroscience, our first long-term closed-loop ES experiment results as the proof-of-feasibility of the method, and our paradigm-shifting proposal of dialogical bio-ICT paradigms. acceptedVersion |
| Databáze: | OpenAIRE |
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