Mycobacterium alvei (ω-1)-methoxy mycolic acids: Absolute stereochemistry and synthesis
| Autor: | Ahmad R. Al Dulayymi, Zamzam S. Alhuwaymil, Paul J. Gates, Mark S. Baird, Pedro L. Valero-Guillén, Intisar Q. M. Alaraj, Juma'a R. Al Dulayymi, Alison Jones |
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| Rok vydání: | 2020 |
| Předmět: |
Diene
synthesis Stereochemistry 030303 biophysics Substituent (w-1)-methoxy Biochemistry Mycolic acid Mycobacterium 03 medical and health sciences chemistry.chemical_compound alvei Biosynthesis mycolic acid Molecular Biology Mycobacteriaceae 030304 developmental biology chemistry.chemical_classification 0303 health sciences biology Molecular Structure Chemistry Organic Chemistry Stereoisomerism Cell Biology biology.organism_classification Enzyme Mycolic Acids Mycobacterium alvei |
| Zdroj: | Alhuwaymil, Z S, Al-araj, I Q M, Al Dulayymi, A R, Jones, A, Valero-Guillén, P L, Gates, P J, Baird, M S & Al Dulayymi, J R 2020, ' Mycobacterium alvei (ω-1)-methoxy mycolic acids: absolute stereochemistry and synthesis ', Chemistry and Physics of Lipids . https://doi.org/10.1016/j.chemphyslip.2020.104977 |
| ISSN: | 1873-2941 |
| DOI: | 10.1016/j.chemphyslip.2020.104977 |
| Popis: | Cells of Mycobacterium alvei are known to contain a unique set of mycolic acids with a (ω-1)-methoxy group; although the various enzymes in the biosynthesis of other types of mycolic acid have been widely studied, the biosynthetic route to this substituent is unclear. We now define the stereochemistry of the (ω-1)-methoxy fragment as R, and describe the synthesis of a major R-(ω-1)-methoxy-mycolic acid and its sugar esters, and of two natural M. alvei diene mycolic acids. |
| Databáze: | OpenAIRE |
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