Neuropsychological, Metabolic, and GABAAReceptor Studies in Subjects with Repetitive Traumatic Brain Injury
| Autor: | Byung Seok Moon, Seong Ae Bang, Yoo Sung Song, Byung Chul Lee, Jong Min Kim, Sang Eun Kim, Ho Young Lee |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Flumazenil Male Fluorine Radioisotopes medicine.medical_specialty Traumatic brain injury Poison control Brain damage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Degenerative disease Neuroimaging Brain Injuries Traumatic medicine Humans Cognitive Dysfunction GABA Modulators Psychiatry Cerebral Cortex Memory Disorders medicine.diagnostic_test business.industry Neuropsychology Neuropsychological test Boxing Middle Aged Receptors GABA-A medicine.disease Magnetic Resonance Imaging Chronic traumatic encephalopathy Positron-Emission Tomography Athletic Injuries Neurology (clinical) medicine.symptom business Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurotrauma. 33:1005-1014 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/neu.2015.4051 |
| Popis: | Repetitive traumatic brain injury (rTBI) occurs as a result of mild and accumulative brain damage. A prototype of rTBI is chronic traumatic encephalopathy (CTE), which is a degenerative disease that occurs in patients with histories of multiple concussions or head injuries. Boxers have been the most commonly studied patient group because they may experience thousands of subconcussive hits over the course of a career. This study examined the consequences of rTBI with structural brain imaging and biomolecular imaging and investigated whether the neuropsychological features of rTBI were related to the findings of the imaging studies. Five retired professional boxers (mean age, 46.8 ± 3.19 years) and four age-matched controls (mean age, 48.5 ± 3.32 years) were studied. Cognitive-motor related functional impairment was assessed, and all subjects underwent neuropsychological evaluation and behavioral tasks, as well as structural brain imaging and functional-molecular imaging. In neuropsychological tests, boxers showed deficits in delayed retrieval of visuospatial memory and motor coordination, which had a meaningful relationship with biomolecular imaging results indicative of neuronal injury. Morphometric abnormalities were not found in professional boxers by structural magnetic resonance imaging (MRI). Glucose metabolism was impaired in frontal areas associated with cognitive dysfunction, similar to findings in Alzheimer's disease. Low binding potential (BP) of (18)F-flumazenil (FMZ) was found in the angular gyrus and temporal cortical regions, revealing neuronal deficits. These results suggested that cognitive impairment and motor dysfunction reflect chronic damage to neurons in professional boxers with rTBI. |
| Databáze: | OpenAIRE |
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