The effect of ketorolac on postoperative febrile episodes in patients after abdominal myomectomy
| Autor: | Barbara I. Held, Anne Michels, Charles Ascher-Walsh, Jody S. Blanco |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Fever medicine.medical_treatment Logistic regression Hysterectomy Placebos Gynecologic Surgical Procedures Postoperative Complications Double-Blind Method medicine Humans Prospective Studies Saline business.industry Incidence (epidemiology) Confounding Anti-Inflammatory Agents Non-Steroidal Obstetrics and Gynecology medicine.disease Surgery Ketorolac Regimen Leiomyoma Logistic Models In utero Anesthesia Myometrium Female business medicine.drug |
| Zdroj: | American journal of obstetrics and gynecology. 187(6) |
| ISSN: | 0002-9378 |
| Popis: | Objective: Our purpose was to determine whether administering the anti-inflammatory agent ketorolac after abdominal myomectomy reduces the incidence of febrile episodes. Study Design: This prospective, randomized, double-blinded, placebo-controlled clinical investigation compared administering ketorolac 15 mg intravenously every 6 hours beginning in the recovery room with saline solution administered in the same regimen in 122 patients undergoing abdominal myomectomy in a large, urban academic medical center. The primary outcome was fever >101.0°F in the postoperative period. Results were analyzed by χ 2 analysis, independent samples t test, and logistic regression. Results: Data were analyzed on 112 patients, with 56 in the treatment group and 56 in the placebo group. After confounding factors were controlled with logistic regression, the data revealed a statistically significant reduction in febrile episodes in the ketorolac-treated group (27%) compared with the saline solution-treated group (41%) ( P =.04). Conclusion: Treatment with ketorolac after abdominal myomectomy results in a statistically significant reduction in the rate of febrile episodes. (Am J Obstet Gynecol 2002;187:1450-5.) |
| Databáze: | OpenAIRE |
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