Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori
| ISSN: | 1098-6596 0066-4804 |
|---|---|
| DOI: | 10.1128/aac.40.2.477 |
| Přístupová URL adresa: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eda36b4ef4f606c955a956bfac34a6 https://doi.org/10.1128/aac.40.2.477 |
| Rights: | OPEN |
| Přírůstkové číslo: | edsair.doi.dedup.....04eda36b4ef4f606c955a956bfac34a6 |
| Autor: | David Y. Graham, James Versalovic, K. Kibler, R. K. Flamm, S. K. Tanaka, M. V. Griffy, Mae F. Go, D. Shortridge, J. Beyer |
| Rok vydání: | 1996 |
| Předmět: |
Molecular Sequence Data
Microbial Sensitivity Tests Drug resistance medicine.disease_cause Microbiology 23S ribosomal RNA Clarithromycin Sequence Homology Nucleic Acid medicine Pharmacology (medical) Escherichia coli Antibacterial agent Electrophoresis Agar Gel Protein Synthesis Inhibitors Pharmacology Mutation Base Sequence Helicobacter pylori biology Transition (genetics) Drug Resistance Microbial Ribosomal RNA bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents RNA Ribosomal 23S Infectious Diseases Research Article |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.40.2.477 |
| Popis: | Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin-susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens. |
| Databáze: | OpenAIRE |
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