Treatment patterns for ductal carcinoma in situ with close or positive mastectomy margins
| Autor: | Caroline E. Jones, Catherine Parker, Audrey S. Wallace, Marshall M. Urist, Joshua S. Richman, Helen Krontiras, Bradford E. Jackson, Kirby I. Bland |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Continuous variable 03 medical and health sciences 0302 clinical medicine medicine Humans Effective treatment In patient 030212 general & internal medicine Mastectomy Aged Retrospective Studies business.industry Endocrine therapy Margins of Excision Cancer Middle Aged Ductal carcinoma medicine.disease Carcinoma Intraductal Noninfiltrating 030220 oncology & carcinogenesis Insurance status Female Surgery Radiology business |
| Zdroj: | Journal of Surgical Research. 231:36-42 |
| ISSN: | 0022-4804 |
| Popis: | BACKGROUND Mastectomy remains an effective treatment for ductal carcinoma in situ (DCIS) but whether further therapy is warranted for close or positive margins is controversial. We aim to characterize the treatment practices of DCIS throughout the United States in patients who undergo mastectomy with close or positive margins to better understand the use of postmastectomy radiation therapy (PMRT). MATERIALS AND METHODS Using the 2004-2013 National Cancer Database, we identified all female patients with a diagnosis of DCIS who underwent mastectomy. Distributional characteristics were summarized for overall and margin-stratified samples. Characteristic differences were assessed by region and receipt of radiation. Chi-square and independent sample t-tests were used to assess differences for categorical and continuous variables, respectively. RESULTS In 21,591 patients who met inclusion criteria, 470 patients with close/positive margins were identified. Sixteen percent of patients with close/positive margins received PMRT compared to 1.5% with negative margins (P |
| Databáze: | OpenAIRE |
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