Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats
| Autor: | N. P. Breitkopf, J. L. Williams, Kathleen M. Eyster, Doug Martin |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Mean arterial pressure
medicine.medical_specialty Physiology Ganglionic Blockers Ovariectomy Ganglionic blocker Blood Pressure Nitric Oxide Rats Inbred WKY Chlorisondamine Nitric oxide chemistry.chemical_compound Heart Rate Physiology (medical) Internal medicine Physical Stimulation Rats Inbred SHR medicine Animals Enzyme Inhibitors biology business.industry Caseins Isoflavones Genistein Diet Rats Nitric oxide synthase Endocrinology Blood pressure NG-Nitroarginine Methyl Ester chemistry Hypertension Ovariectomized rat biology.protein Female Soybeans business circulatory and respiratory physiology |
| Zdroj: | American journal of physiology. Regulatory, integrative and comparative physiology. 281(2) |
| ISSN: | 0363-6119 |
| Popis: | This study tested the hypothesis that dietary soy would attenuate the development of hypertension in female spontaneously hypertensive rats (SHR). Female SHR and control Wistar-Kyoto rats were obtained at 4 wk of age, randomly assigned to either an ovariectomized (OVX) group or a sham-operated group, and placed on a soy diet or control casein diet. After a minimum of 8 wk on their respective diets, mean arterial pressure (MAP) and heart rate (HR) were recorded before and after inhibition of nitric oxide synthase, air-jet stress, or ganglionic blockade. The major finding of this study is that MAP was reduced in the OVX SHR consuming soy diet compared with the casein-fed controls (150 ± 4 vs. 164 ± 3 mmHg). Plasma genistein concentrations were increased in the soy-fed OVX SHR (1.23 ± 0.31 μM) compared with the casein-fed OVX SHR (nondetectable). However, there was no difference in plasma genistein concentrations between sham-operated and OVX SHR (1.37 ± 0.42 vs. 1.23 ± 0.31 μM). Inhibition of nitric oxide synthase increased MAP and decreased HR in all groups; diet did not affect this response. Air-jet stress increased MAP and HR in all groups. However, these responses were exaggerated in the soy-fed SHR. Finally, ganglionic blockade abolished the antihypertensive effect of soy diet in the OVX SHR. These findings indicate that dietary soy exerts an antihypertensive effect in OVX SHR. This effect does not involve the nitric oxide system but may be related to an as yet undefined interaction with the autonomic nervous system. |
| Databáze: | OpenAIRE |
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