Effect of exendin-4 treatment upon glucose uptake parameters in rat liver and muscle, in normal and type 2 diabetic state
| Autor: | Luis Arnes, Bernardo Nuche-Berenguer, Isabel Valverde, María Luisa Villanueva-Peñacarrillo, Paola Moreno |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Agonist endocrine system medicine.medical_specialty endocrine system diseases Physiology medicine.drug_class Glucose uptake Clinical Biochemistry Biology Carbohydrate metabolism Biochemistry Glucagon-Like Peptide-1 Receptor Diabetes Mellitus Experimental Cellular and Molecular Neuroscience chemistry.chemical_compound Endocrinology Internal medicine Receptors Glucagon medicine Animals Rats Wistar Muscle Skeletal Receptor Glycogen Venoms digestive oral and skin physiology Glucose transporter nutritional and metabolic diseases Skeletal muscle Rats Glucose medicine.anatomical_structure Diabetes Mellitus Type 2 Liver chemistry Gastrointestinal hormone Exenatide Peptides hormones hormone substitutes and hormone antagonists |
| Zdroj: | Regulatory Peptides. 153:88-92 |
| ISSN: | 0167-0115 |
| Popis: | Exendin-4, like GLP-1, is insulinotropic, antidiabetic and glucoregulatory among other properties, which are thought to be exerted through the pancreatic GLP-1 receptor; exendin-4 is also an agonist of the GLP-1 stimulatory action upon liver and muscle glucose metabolism, where GLP-1 receptor is distinct from that in the pancreas. We investigated the action of prolonged treatment with exendin-4 upon glucose transport parameters in skeletal muscle and liver of normal rats and streptozotocin-induced type 2 diabetic rats (T2D). Muscle of T2D showed lower than normal glucose transport; exendin-4 did not modify the value in normal but normalized that in the T2D; unlike previously detected with GLP-1, no apparent modification was observed in GLUT-4 expression in either group after exendin-4, except for an increased GLUT-4 protein in normal rats. Yet, exendin-4 significantly stimulated liver GLUT-2-mRNA and -protein in T2D and normal rats, the effect upon GLUT-2-protein in T2D being higher than that in normal animals; this was accompanied by a normalizing action of exendin-4 upon the lower than normal liver glycogen in T2D rats. These data suggest that the liver may represent at least one of the major target organs for exendin-4 to exert its plasma lowering effect in diabetic state. |
| Databáze: | OpenAIRE |
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