Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer
| Autor: | Ildikó Bobok, Csongor Kiss, Edit Bárdi, Anna V. Oláh, János Kappelmayer |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent Urology Renal function Antineoplastic Agents Klinikai orvostudományok Pathology and Forensic Medicine Nephrotoxicity Kidney Tubules Proximal chemistry.chemical_compound Acetylglucosaminidase medicine Albuminuria Humans Idarubicin Anthracyclines Child Epirubicin Retrospective Studies Creatinine Antibiotics Antineoplastic Ifosfamide business.industry Lymphoma Non-Hodgkin Daunorubicin Infant Orvostudományok General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma Carboplatin Surgery Oncology chemistry Doxorubicin Child Preschool Female Kidney Diseases Dexrazoxane Razoxane business medicine.drug |
| Zdroj: | Pathology & Oncology Research. 13:249-253 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/bf02893506 |
| Popis: | Experimental evidence suggests that anthracyclines, widely used in cancer chemotherapy, may impair kidney function. We assessed kidney function by serum creatinine, urinary N-acetyl-beta-D-glucosaminidase activity indices (NAGi) and microalbuminuria (MA) in 160 serum and urine samples obtained from 66 children with cancer. The effect of dexrazoxane was analyzed in 6 children on dexrazoxane supportive therapy in conjunction with daunorubicin (DNR) treatment, as compared with 6 children not receiving this agent. NAGi was significantly (p |
| Databáze: | OpenAIRE |
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