Functionalized C-nucleosides as remarkable RNA binders: targeting of prokaryotic ribosomal A-site RNA
| Autor: | Rachid Benhida, Maria Duca, Lorena Zara, Jean-Patrick Joly, Marc Gaysinski |
|---|---|
| Přispěvatelé: | GRAMAT (DAM/GRAMAT), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Nice Sophia Antipolis Plate-Forme Technologique de Chimie, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Biocapteurs-Analyses-Environnement (BAE), Université de Perpignan Via Domitia (UPVD), Institut de Chimie de Nice (ICN), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Université Nice Sophia Antipolis (... - 2019) (UNS) |
| Rok vydání: | 2019 |
| Předmět: |
010402 general chemistry
01 natural sciences Catalysis [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication Materials Chemistry C nucleosides Nuclear Magnetic Resonance Biomolecular ComputingMilieux_MISCELLANEOUS 010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Circular Dichroism Metals and Alloys RNA Nucleosides General Chemistry Ribosomal RNA 3. Good health 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials A-site Biochemistry RNA Ribosomal Ceramics and Composites Nucleic Acid Conformation Thermodynamics Ribosomes |
| Zdroj: | Chemical Communications Chemical Communications, 2019, 55 (70), pp.10432-10435. ⟨10.1039/c9cc04915k⟩ Chemical Communications, Royal Society of Chemistry, 2019, 55 (70), pp.10432-10435. ⟨10.1039/c9cc04915k⟩ |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | RNA represents an extremely promising and yet challenging therapeutic target. Here, we report the design of a series of C-nucleosides as original RNA binders. Some of them bind strongly and selectively to A-site prokaryotic ribosomal RNA. |
| Databáze: | OpenAIRE |
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