Protective Effects of Methylxanthines on Hypoxia-Induced Apoptotic Neurodegeneration and Long-Term Cognitive Functions in the Developing Rat Brain
| Autor: | Nuray Duman, Sermin Genc, Osman Yilmaz, Sumer Sutcuoglu, Ilkay Aksu, Mustafa Akhisaroglu, Didem Cemile Yesilirmak, Hasan Ozkan, Serap Cilaker, Simge Aykan, Abdullah Kumral, Kazim Tugyan |
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| Rok vydání: | 2010 |
| Předmět: |
Pentobarbital
Apoptosis Cell Count Water maze Hippocampal formation Pharmacology Hippocampus Cognition Memory Pregnancy Image Processing Computer-Assisted Animals Medicine Rats Wistar Maze Learning Apnea of prematurity business.industry Receptors Purinergic P1 Intermittent hypoxia Hypoxia (medical) medicine.disease Aminophylline Adenosine receptor Rats Disease Models Animal Neuroprotective Agents Animals Newborn Anesthesia Hypoxia-Ischemia Brain Nerve Degeneration Pediatrics Perinatology and Child Health Female medicine.symptom business Developmental Biology medicine.drug |
| Zdroj: | Neonatology. 98:128-136 |
| ISSN: | 1661-7819 1661-7800 |
| Popis: | Aminophylline is widely used in the management of premature apnea. The methylxanthines aminophylline, theophylline and caffeine are nonspecific inhibitors of adenosine receptors. There are no proven effects of methylxanthines on acute brain injury and long-term cognitive functions. This study is aimed at investigating the effects of methylxanthines on brain injury and cognitive functions. Newborn rats were allocated to form four groups, which contained at least 21 pups: two groups were exposed to room air and two groups were exposed to intermittent hypoxia. Intraperitoneal aminophylline was administered to treatment groups during postnatal day 1 through postnatal day 7. All rats were sacrificed on postnatal day 8 via intraperitoneal pentobarbital and the effects of the administered drug on brain injury and adenosine receptor expression were determined. Cognitive functions of rats were evaluated via water maze test. Histopathological evaluation demonstrated that aminophylline significantly diminished the number of 'apopto tic cells' in the hippocampal CA1, CA2, CA3 and gyrus dentatus regions in the brain. Aminophylline treatment immediately after hypoxic insult significantly improved long-term neurobehavioral achievements. In conclusion, aminophylline administration immediately after neonatal hypoxic insult provides benefit over a prolonged period in the developing rat brain. Copyright (C) 2010 S. Karger AG, Basel |
| Databáze: | OpenAIRE |
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