Use of Polyetherurethane to Improve the Biocompatibility of Vascular Stents
| Autor: | Arthur B. Fontaine, Dimitrios G. Spigos, Jody Cearlock, Alberto Urbaneja, Susan Dos Passos |
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| Rok vydání: | 1995 |
| Předmět: |
Neointima
Biocompatibility Swine medicine.medical_treatment Biocompatible Materials Tantalum 030204 cardiovascular system & hematology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Renal Artery medicine Animals Radiology Nuclear Medicine and imaging Polytetrafluoroethylene Hyperplasia business.industry Stent Equipment Design Internal elastic lamina Vascular stent Surgery Stents Tunica Intima Cardiology and Cardiovascular Medicine business Differential growth Biomedical engineering |
| Zdroj: | Journal of Endovascular Surgery. 2:255-265 |
| ISSN: | 1074-6218 |
| DOI: | 10.1583/1074-6218(1995)002<0255:uoptit>2.0.co;2 |
| Popis: | Purpose: To investigate potential differential growth of neointima following overdilating arterial trauma with polyetherurethane-coated versus bare metalìc stents in swine. Methods: Twelve specially constructed tantalum stents, 6 coated with polyetherurethane block copolymer and 6 uncoated, were overdilated by 25% in 12 normal renal arteries of six swine. The stents were harvested 8 weeks after implantation and prepared for histologic examination. Neointimal thickness was quantified and analyzed for significant differences between coated and uncoated prostheses. Results: All specimens demonstrated fractures of the internal elastic lamina consistent with vascular injury. There was significantly less neointimal formation (0.0001 < p < 0.05) in coated specimens as compared to uncoated controls in each test animal. Conclusion: The vascular response to overdilating stent trauma appears to be moderated with the use of polyetherurethane block copolymer as compared to control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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