Lessons from extreme human obesity: monogenic disorders
| Autor: | Christian Vaisse, Sayali A. Ranadive |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Leptin
medicine.medical_specialty Pro-Opiomelanocortin Single-Gene Defects Endocrinology Diabetes and Metabolism Monogenic Obesity medicine.disease_cause Body weight Article Endocrinology Internal medicine medicine Basic Helix-Loop-Helix Transcription Factors Humans Obesity Gene Bardet-Biedl Syndrome Human obesity Genetics Mutation business.industry Brain-Derived Neurotrophic Factor medicine.disease Phenotype Repressor Proteins Proprotein Convertase 1 Receptor Melanocortin Type 4 Receptors Leptin business |
| Zdroj: | Endocrinology and metabolism clinics of North America. 37(3) |
| ISSN: | 0889-8529 |
| Popis: | There is a strong genetic component to human obesity. Most genes that influence an individual’s predisposition to gain weight are not yet known. However, a glimpse into the long-term regulation of body weight has come from studying extreme human obesity caused by single gene defects. These monogenic obesity disorders have confirmed that the hypothalamic leptin-melanocortin system is critical for energy balance in humans because disruption of these pathways causes the most severe obesity phenotypes. Approximately 20 different genes and at least 3 different mechanisms implicated in monogenic causes of obesity have been identified, however, they account for less than 5% of all severe obesity. This suggests that the genetic basis for human obesity is likely to be extremely heterogeneous, with contribution from numerous different genes acting by various, yet undiscovered, molecular mechanisms. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|